Research progress on detection techniques for effective albumin concentration
10.3760/cma.j.cn501113-20240308-00122
- VernacularTitle:有效白蛋白检测技术研究进展
- Author:
Mengqi LI
1
;
Yidi GE
;
Wen XIE
Author Information
1. 首都医科大学附属北京地坛医院肝病中心，北京 100015
- Keywords:
Liver cirrhosis;
Effective albumin;
Liquid chromatography tandem mass spectrometry;
Electron paramagnetic resonance
- From:
Chinese Journal of Hepatology
2024;32(6):493-496
- CountryChina
- Language:Chinese
-
Abstract:
Hypoalbuminemia is one of the important clinical features of decompensated cirrhosis. As the disease progresses, not only does the total albumin concentration decrease, but so does the proportion of albumin that remains structurally and functionally intact. The structural and functional integrity of albumin is essential for its normal physiological role in the body. This led to the concept of "effective albumin concentration," which may be much lower than the total albumin concentration routinely measured clinically in patients with advanced cirrhosis. Liquid chromatography-tandem mass spectrometry, and electron paramagnetic resonance (EMR) are emerging technologies for effective albumin concentration detection, showing promising clinical application prospects, but research in patients with cirrhosis is still in the preliminary stage. Therefore, this article will comprehensively summarize the latest research on the aspects of effective albumin detection methods, liquid chromatography-tandem mass spectrometry, and electron paramagnetic resonance, as well as their applications.
