Post-transcriptional regulation mechanism and antiviral strategy of hepatitis B virus RNA
10.3760/cma.j.cn501113-20240410-00191
- VernacularTitle:乙型肝炎病毒RNA的转录后调控机制及抗病毒策略
- Author:
Deyao LI
1
;
Danjuan LU
;
Chenxiao QU
;
Ting ZHANG
;
Jia LIU
;
Fengmin LU
;
Xiangmei CHEN
Author Information
1. 北京大学基础医学院病原生物学系暨感染病研究中心，北京 100191
- Keywords:
Chronic hepatitis B;
Hepatitis B virus;
Post-transcriptional regulation;
Antivirulence;
Thera peutic
- From:
Chinese Journal of Hepatology
2024;32(5):474-480
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B virus (HBV) infection is one of the major public health issues of ongoing global concern. Due to inadequate understanding of the HBV life cycle, there is a lack of effective drugs to cure chronic hepatitis B. During HBV replication, covalently closed circular DNA (cccDNA) serves as the template for viral replication and can be transcribed to produce five viral RNAs of 3.5, 2.4, 2.1 kb and 0.7 kb in length, which are translated to produce HBeAg, core protein, polymerase (P) protein, HBsAg and HBx proteins, respectively. Among them, the 3.5 kb pregenomic RNA (pgRNA) is also the template for viral reverse transcription. Polymerase protein recognizes and binds to the capsid assembly signal on the pgRNA to initiate capsid assembly and reverse transcription. Recent studies have revealed that the processes of splicing, nuclear export, stability, translation, and pgRNA encapsidation of HBV RNAs are regulated by a post-transcriptional regulatory network within the host cell and depend on unique post-transcriptional regulatory elements in the HBV RNA structure. The aim of this review is to overview the post-transcriptional regulatory mechanisms of HBV RNA and their applications in the study of HBV antiviral therapeutics, with the aim of providing new ideas for the development of new drugs targeting HBV RNA.
