Research progress of lactate dehydrogenase in the diagnosis and treatment of gastric cancer

VernacularTitle:乳酸脱氢酶在胃癌诊治中的研究进展
Author: Jun LIAO ¹ ; Chunfeng LI ; Yingwei XUE ; Hongliang ZU
Author Information

1. 广东医科大学第一临床医学院(湛江 524000)
Keywords: Tumor glycolysis; Lactate dehydrogenase; Prognosis of gastric cancer; Prediction model of gastric cancer
From: Practical Oncology Journal 2024;38(3):200-206
CountryChina
Language:Chinese
Abstract: China is the rank 1st of gastric cancer in the world,and the incidence and mortality of gastric cancer rank the 3rd among various malignant tumors in China.It has been found that tumor cells have their own energy metabolism characteristics.Even in the presence of sufficient oxygen,tumor cells are more inclined to use glycolysis to produce energy,also known as"aerobic glycoly-sis".Aerobic glycolysis can lead to an increase in lactate,promoting the acceleration of tumor cell proliferation and invasiveness,and the key enzyme driving this phenomenon is lactate dehydrogenase(LDH).LDH levels are significantly elevated in patients with gas-tric cancer,and LDH can contribute to the occurrence and development of gastric cancer in many ways.This article will discuss the role of LDH in tumor glycolysis,which is correlated with gastric cancer as well as its clinical application value.It will also discuss the research progress of LDH in targeted therapy for gastric cancer.