Research progress in the regulation of pathogenesis and the transformation of chronic liver disease by short-chain fatty acids
10.3760/cma.j.cn501113-20231118-00203
- VernacularTitle:短链脂肪酸调节慢性肝病发病与转归的研究进展
- Author:
Qianqian JIN
1
;
Shusheng LIAO
;
Yue QIN
;
Xiaoguang DOU
;
Chong ZHANG
Author Information
1. 中国医科大学附属盛京医院感染科，沈阳 110022
- Keywords:
Short-chain fatty acid;
Intestinal flora;
Gut-liver axis;
Chronic liver disease
- From:
Chinese Journal of Hepatology
2024;32(3):268-272
- CountryChina
- Language:Chinese
-
Abstract:
Short-chain fatty acids are metabolites of the intestinal flora and serve as the main energy source for intestinal epithelial cells. At the same time, as important signaling molecules, it regulate a variety of cellular inflammatory responses and homeostatic proliferation through receptor-dependent and independent pathways. Short-chain fatty acids regulate the gut-liver axis and thereby directly act on the liver, participating in the pathogenesis and transformation of various liver diseases, including alcoholic liver disease, metabolic dysfunction-related liver disease, autoimmune liver disease, liver fibrosis, and hepatocellular carcinoma. In addition, short-chain fatty acids can inhibit HBV DNA replication. This article reviews the research progress on the role of short-chain fatty acids in aspects of the pathogenesis and transformation of chronic liver diseases.
