An analysis on clinical characteristics and prognosis-related risk factors in patients with drug-induced liver injury
10.3760/cma.j.cn501113-20240201-00072
- VernacularTitle:药物性肝损伤患者的临床特征及预后相关危险因素分析
- Author:
Qian WEI
1
;
Lei LI
;
Xiaoqing ZENG
;
Abidan Bai He Ti Ya Er
;
Jie YIN
;
Hong GAO
;
Jinsheng GUO
Author Information
1. 复旦大学附属中山医院消化科 上海市肝病研究所，上海 200032
- Keywords:
Drug-induced liver injury;
Liver failure;
Chronicity;
Risk factor;
Chinese medicine
- From:
Chinese Journal of Hepatology
2024;32(3):214-221
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the drugs and clinical characteristics causing drug-induced liver injury (DILI) in recent years, as well as identify drug-induced liver failure, and chronic DILI risk factors, in order to better manage them timely.Methods:A retrospective investigation and analysis was conducted on 224 cases diagnosed with DILI and followed up for at least six months between January 2018 and December 2020. Univariate and multivariate logistic regression analyses were used to identify risk factors for drug-induced liver failure and chronic DILI.Results:Traditional Chinese medicine (accounting for 62.5%), herbal medicine (accounting for 84.3% of traditional Chinese medicine), and some Chinese patent medicines were the main causes of DILI found in this study. Severe and chronic DILI was associated with cholestatic type. Preexisting gallbladder disease, initial total bilirubin, initial prothrombin time, and initial antinuclear antibody titer were independent risk factors for DILI. Prolonged time interval between alkaline phosphatase (ALP) and alanine aminotransferase (ALT) falling from the peak to half of the peak (T 0.5ALP and T 0.5ALT) was an independent risk factor for chronic DILI [area under the receiver operating characteristic curve (AUC)?=?0.787, 95%CI: 0.697~0.878, P ?
