Research progress on the role of hepatitis B virus DNA integration in chronic hepatitis B
10.3760/cma.j.cn501113-20231107-00177
- VernacularTitle:乙型肝炎病毒整合DNA在慢性乙型肝炎中的作用研究进展
- Author:
Yuanmei CHEN
1
;
Jin LIU
;
Chuanwu ZHU
;
Li ZHU
Author Information
1. 苏州大学附属传染病医院肝病科，苏州 215131
- Keywords:
Hepatitis B virus;
Integrated HBV DNA;
Chronic hepatitis B virus infection;
Viral replication;
Functional cure
- From:
Chinese Journal of Hepatology
2024;32(2):164-167
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B virus (HBV) infection will greatly contribute to raising the occurrence probability of cirrhosis and hepatocellular carcinoma in patients. Although existing antiviral treatment regimens have a certain effect on delaying disease progression and improving prognosis, it is still not effective in attaining functional cures. Hepatitis B virus DNA integration may be one of the reasons for this phenomenon. Therefore, this paper reviews the possible mechanisms of HBV DNA integration in maintaining chronic inflammation of the liver, evading existing antiviral treatment methods, and inducing hepatocellular carcinoma so as to further deepen the understanding of the role of HBV DNA integration in the occurrence and development of chronic hepatitis B, providing ideas and references for formulating better treatment strategies.
