Research progress of cuprotosis in tumors

VernacularTitle:铜死亡在肿瘤中的研究进展
Author: Yuan GAO ¹ ; Yuhan TANG ; Lu WANG ; Wenhui ZHAO
Author Information

1. 哈尔滨医科大学附属肿瘤医院乳腺肿瘤内科一科室(哈尔滨 150081)
Keywords: Cuprotosis; Tumor; Cell death; Regulated cell death
From: Practical Oncology Journal 2024;38(1):50-54
CountryChina
Language:Chinese
Abstract: Copper is an indispensable trace element in living organisms and maintains at a certain level in cells under physio-logical conditions.Cuprotosis is a unique,copper-dependent cell death.It is an extremely important type of regulated cell death(RCD)and is different from other forms of cell death currently known.More and more studies have shown that cuprotosis has a non-negligible impact on the metabolic pathway transition,signaling pathway transduction,and protein processing and modification of tumor cells.Cuprotosis-related lncRNAs are also widely used to predict tumor prognosis.Cuprotosis can inhibit tumor cell growth and serve as a potential target for controlling drug resistance and disease recurrence.This article reviews the mechanism of cuprotosis in the de-velopment and progression of tumor cells.