A real-world study on the features of postpartum hepatitis flares in pregnant women with chronic HBV infection
10.3760/cma.j.cn501113-20231122-00216
- VernacularTitle:慢性HBV感染孕妇分娩后肝炎发作特点的真实世界研究
- Author:
Zhan ZENG
1
;
Mingfang ZHOU
;
Yanjie LIN
;
Xiaoyue BI
;
Liu YANG
;
Wen DENG
;
Tingting JIANG
;
Leiping HU
;
Mengjiao XU
;
Lu ZHANG
;
Wei YI
;
Minghui LI
Author Information
1. 北京大学地坛医院教学医院肝病二科，北京 100015
- Keywords:
Pregnancy;
Hepatitis;
Chronic HBV infection
- From:
Chinese Journal of Hepatology
2024;32(2):113-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical features of postpartum hepatitis flares in pregnant women with hepatitis B virus (HBV) infection.Methods:A retrospective study was conducted. Patients who met the enrollment criteria were included. Liver function and HBV virology tests were collected from pregnant women with chronic HBV infection at delivery, 6, 24, 36, and 48 weeks after delivery through the hospital information and test system. Additionally, antiviral therapy types and drug withdrawal times were collected. Statistical analysis was performed on all the resulting data.Results:A total of 533 pregnant women who met the inclusion criteria were included, with all patients aged (29.5±3.7) years old. A total of 408 cases received antiviral drugs during pregnancy to interrupt mother-to-child transmission. There was no significant difference in the levels of alanine aminotransferase (ALT, z ?=?-1.981, P ?=?0.048), aspartate aminotransferase (AST, z ?=?-3.956, P ?
