Research progress of direct-acting antiviral drugs in the treatment of chronic hepatitis C-related cirrhosis
10.3760/cma.j.cn501113-20231126-00237-1
- VernacularTitle:直接抗病毒药物治疗慢性丙型肝炎肝硬化的研究进展
- Author:
Youfei ZHAO
1
;
Liang XU
;
Yuqiang MI
Author Information
1. 天津医科大学第二人民医院临床学院，天津 300070
- Keywords:
Hepatitis C virus;
Liver cirrhosis;
Hepatocellular carcinoma;
Liver transplantation;
Direct-acting antiviral agents
- From:
Chinese Journal of Hepatology
2024;32(1):87-90
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis C is a kind of viral hepatitis caused by hepatitis C virus infection, which can further progress to cirrhosis, liver failure, hepatocellular carcinoma, and even death. Presently, there is no preventive vaccine yet. Therefore, preventing infection and safe and effective drug treatment are currently the most effective strategies for dealing with hepatitis C virus infection. Since 2014, the clinical application of direct-acting antiviral drugs has brought revolutionary changes to the treatment of chronic hepatitis C. Direct-acting antiviral drugs have an excellent hepatitis C virus clearance effect, are well tolerated, have a good safety profile, and can significantly improve liver function, metabolic disorders, immune dysfunction, etc. However, some studies have pointed out that even if the hepatitis C virus is cleared during the treatment of chronic hepatitis C-related cirrhosis with direct-acting antiviral drugs, a considerable proportion of patients still have severe liver failure, hepatocellular carcinoma, and even liver disease-related death, so there are still some problems in the treatment of chronic hepatitis C- related cirrhosis with direct-acting antiviral drugs that need to be further explored. This article reviews the research progress of direct-acting antiviral drugs so as to provide meaningful references for the treatment of patients with chronic hepatitis C-related cirrhosis.
