The role of glutamine metabolic reprogramming in macrophages in cardiovascular disease
10.3969/j.issn.1006-5725.2024.22.024
- VernacularTitle:巨噬细胞的谷氨酰胺代谢重编程在心血管疾病中的作用
- Author:
Xing CHEN
1
;
Yan DENG
Author Information
1. 广西医科大学第一附属医院超声科(广西 南宁 530021)
- Keywords:
glutamine metabolism;
macrophages;
cardiovascular disease;
metabolic reprogramming
- From:
The Journal of Practical Medicine
2024;40(22):3262-3267
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease(CVD)poses a significant public health challenge in China,with both incidence and mortality rates increasing.The role of macrophage metabolic reprogramming in CVD has garnered growing attention due to its direct connection to the pathogenesis of the disease and potential therapeutic interven-tions.Glutamine(GLN),a fundamental energy source for macrophages,plays a crucial role in this context.Altera-tions in GLN metabolism have substantial effects on macrophage phenotypic transformation,functional performance,and adaptive responses in the context of CVD.Therefore,this review aims to investigate the impact of GLN metabolic reprogramming on macrophages'contribution to the pathogenesis of CVD,specifically focusing on its involvement in atherosclerosis,myocardial infarction,and other cardiovascular conditions.Additionally,it will evaluate the poten-tial of targeting GLN metabolic pathways as a therapeutic strategy.
