The prognostic value of serum cystatin C combined with bedside renal ultrasound in patients with sepsis-induced acute kidney injury
10.3969/j.issn.1006-5725.2024.22.018
- VernacularTitle:血清胱抑素C联合床旁肾脏超声对脓毒症急性肾损伤患者预后情况的评估价值
- Author:
Chengcai DAI
1
;
Zhenxing CHENG
;
Qianqian TU
Author Information
1. 安徽医科大学第一附属医院急诊科(安徽 合肥 230022)
- Keywords:
serum cystatin C;
bedside ultrasound;
sepsis;
acute kidney injury;
poor prognosis
- From:
The Journal of Practical Medicine
2024;40(22):3226-3231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the prognostic significance of serum cystatin C(CysC)in combination with bedside renal ultrasound for patients diagnosed with sepsis-induced acute kidney injury(AKI).Methods The study cohort comprised 134 patients with sepsis-induced AKI who were admitted to our hospital between October 2019 and October 2023.Based on the 30 day prognosis,the patients were categorized into a survival group(n=93)and a death group(n=41).Collected clinical data included gender,age,heart rate,underlying diseases,treat-ment modalities,duration of hospital stay,basic biochemical indicators,and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHEⅡ)scores.Renal function markers such as serum creatinine(SCr),blood urea nitrogen(BUN),and cystatin C levels were measured;renal blood flow resistance index(RI)was assessed using bedside routine ultrasound.Cox regression analysis was employed to evaluate factors influencing poor prognosis in patients with sepsis-induced AKI while analyzing the prognostic assessment value of combining cystatin C with bedside renal ultrasound through ROC curves.Results The death group exhibited significantly higher APACHEⅡ scores,SCr,BUN,CysC levels,and RI(all P<0.05)compared to the survival group.Cox regression analysis revealed that both CysC levels and RI were significant prognostic indicators(P<0.05).ROC curve analysis demonstrated that the combined assessment of CysC levels and RI yielded a high diagnostic accuracy of 97.5%in predicting outcomes for patients with sepsis-induced AKI.Conclusion CysC levels and bedside renal ultrasound can serve as prognostic indicators for patients with sepsis-induced acute kidney injury(AKI),thereby guiding clinical treatment.
