Progress and application of liver organoids in the study of liver cancer
10.3760/cma.j.cn501113-20231107-00178
- VernacularTitle:肝脏类器官在肝癌研究中的进展及其应用
- Author:
Min WANG
1
;
Ziyan XU
;
Chao YU
;
Xinyi ZHANG
;
Hongyong CAO
;
Yong MA
Author Information
1. 南京医科大学附属南京医院（南京市第一医院）普外科，南京 210000
- Keywords:
Primary hepatic carcinoma;
Organoids;
Stem cells
- From:
Chinese Journal of Hepatology
2023;31(12):1332-1335
- CountryChina
- Language:Chinese
-
Abstract:
The incidence rate of liver cancer has been rising in recent years. Traditional cell line culture and human patient-derived tumor xenograft models, which are commonly used tools to simulate the occurrence of human liver cancer, have deepened the understanding of tumor occurrence, development, and drug resistance mechanisms. However, they cannot reflect the accurate state of cancer cells, the tumor microenvironment, or spatial structural characteristics. Recently, more in vitro-produced physiological liver organoids have been applied in the study of liver cancer. Liver organoid models have made breakthroughs in the occurrence and development mechanisms of liver cancer, personalized drug screening and biomarker identification, immunotherapy, and regenerative medicine applications. This paper mainly summarizes the progress and application of liver organoids processed in the study of liver cancer.
