Research progress on AMPK activation in nonalcoholic fatty liver disease
10.3760/cma.j.cn501113-20231107-00176
- VernacularTitle:AMPK激活在非酒精性脂肪性肝病中的研究进展
- Author:
Xinyu YE
1
;
Tongxi LI
;
Zhiwei HUANG
;
Wenguang FU
;
Qiu LI
Author Information
1. 西南医科大学附属医院普通外科（肝胆胰外科） 西南医科大学附属医院四川省院士（专家）工作站，泸州 646000
- Keywords:
Nonalcoholic fatty liver disease;
AMP-dependent protein kinase;
Nonalcoholic steatohepatitis;
Glucose and fat metabolism
- From:
Chinese Journal of Hepatology
2023;31(11):1220-1223
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) occurrence and progression are associated with lipid accumulation, insulin resistance, inflammation, liver damage, fibrosis, and other factors. AMP-dependent protein kinase (AMPK) is a key molecule that regulates bioenergy metabolism and participates in multiple biological processes, including lipid metabolism, autophagy, inflammation, and cell apoptosis. Promoting AMPK activation can reduce hepatic lipid accumulation and insulin resistance, alleviate the development of NAFLD, reduce liver inflammation and fibrosis, and inhibit the progression of NAFLD to nonalcoholic steatohepatitis.
