Progress in clinical research on potential therapeutic drugs for acute-on-chronic liver failure
10.3760/cma.j.cn501113-20220625-00349
- VernacularTitle:慢加急性肝衰竭潜在治疗药物的临床研究进展
- Author:
Zhenghao WU
1
;
Lei ZHENG
;
Meng LUO
Author Information
1. 上海交通大学医学院附属第九人民医院普外科，上海 200011
- Keywords:
Acute-on-chronic liver failure;
Drug therapy;
Portal hypertension;
Sepsis;
Energy metabolism disorder;
Oxidative stress;
Apoptosis
- From:
Chinese Journal of Hepatology
2023;31(10):1117-1120
- CountryChina
- Language:Chinese
-
Abstract:
Acute-on-chronic liver failure (ACLF), has a high mortality rate and a poor prognosis. Currently, the only effective treatment for ACLF is liver transplantation. However, the number of patients who can successfully undergo liver transplantation is limited due to the rapid progression of ACLF, the occurrence of serious complications, and a dearth of liver donors. The available drug treatment indication expansion and pathogenesis exploration are expected to delay the progression of ACLF, reduce complications, and provide patients with opportunities for liver transplantation by improving portal vein pressure, inhibiting excessive inflammatory response, correcting energy metabolism disorders, reducing oxidative stress, resisting hepatic cell apoptosis, and promoting liver regeneration.
