Research progress on the mechanism and response strategies of molecular targeted drug resistance in liver cancer
10.3760/cma.j.cn501113-20220723-00393
- VernacularTitle:肝癌分子靶向药物耐药机制及其应对策略研究进展
- Author:
Meifang SONG
1
;
Luyuan MA
;
Qian ZHAO
;
Chuan SHEN
;
Caiyan ZHAO
Author Information
1. 河北医科大学第三医院感染科，石家庄 050051
- Keywords:
Hepatocellular carcinoma;
Drug resistance mechanism;
Coping strategies
- From:
Chinese Journal of Hepatology
2023;31(10):1108-1112
- CountryChina
- Language:Chinese
-
Abstract:
Molecular targeted drugs are one of the treatments for hepatocellular carcinoma (HCC), the primary factor influencing their therapeutic efficacy is drug resistance. Diminished drug intake, greater efflux, improved DNA damage repair capacity, aberrant signal pathways, hypoxia, epithelial-mesenchymal cell transition, and the cellular autophagy system are summarized herein as aspects of the drug resistance mechanism. Simultaneously, effective strategies for addressing drug resistance are elaborated, providing ideas for better clinical treatment of HCC.
