Research progress of matrix metalloproteinase-28 in pulmonary disease
10.3969/j.issn.1006-5725.2024.20.021
- VernacularTitle:基质金属蛋白酶-28在肺部疾病中的研究进展
- Author:
Ling TAN
1
;
Xue MA
;
Jingjing WANG
;
Fengfeng LEI
Author Information
1. 兰州大学第一临床医学院(甘肃兰州 730000)
- Keywords:
matrix metalloproteinase-28;
pulmonary disease;
regulatory mechanism
- From:
The Journal of Practical Medicine
2024;40(20):2949-2953
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinase-28(MMP-28)is widely expressed in vertebrates and plays diverse biological roles,participating in the regulation of various pathophysiological processes in the body.Increased expression of MMP-28 has been observed in chronic obstructive pulmonary disease,pulmonary fibrosis,and other lung diseases.Studies have demonstrated that MMP-28 promotes chronic inflammation and tissue remodeling by regulating macrophage recruitment and M2 polarization,and is involved in the pathogenesis of lung diseases by promoting cell proliferation and epithelial-mesenchymal transition.This article provides a review of the relationship between the basic characteristics of MMP-28 and pulmonary diseases.
