Chinese expert guidance on overall application of lenvatinib in hepatocellular carcinoma
10.3760/cma.j.cn115610-20230201-00035-1
- VernacularTitle:仑伐替尼肝癌全病程应用中国专家指导意见
- Author:
Xinrong YANG
1
;
Huichuan SUN
;
Qing XIE
;
Wanguang ZHANG
;
Weidong JIA
;
Ming ZHAO
;
Haitao ZHAO
;
Xiufeng LIU
;
Ledu ZHOU
;
Sheng YAN
;
Li XU
;
Nanya WANG
;
Yuan DING
;
Xiaodong ZHU
;
Jian ZHOU
;
Jia FAN
Author Information
1. 复旦大学附属中山医院肝脏外科 肝癌研究所，上海 200032
- Keywords:
Liver neoplasms;
Lenvatinib;
Hepatocellular carcinoma;
Systemic treat-ment;
Overall management;
Reasonable application;
Safety
- From:
Chinese Journal of Hepatology
2023;31(10):1018-1029
- CountryChina
- Language:Chinese
-
Abstract:
Lenvatinib mesylate is an oral receptor tyrosine kinase inhibitor against targets of vascular endothelial growth factor receptors 1-3, fibroblast growth factor receptors 1-4, platelet-derived growth factor receptor α, stem cell growth factor receptor, and rearranged during transfection, et al. Lenvatinib has been approved by the National Medical Products Administration of China on September 4, 2018, for the first-line treatment of patients with unresectable hepatocellular carcinoma who have not received systematic treatment before. Up to February 2023, Lenvatinib has been listed in China for more than 4 years, accumulating a series of post-marketing clinical research evidences. Based on the clinical practice before and after the launch of lenvatinib and referring to the clinical experience of other anti-angiogenesis inhibitors, domestic multidisciplinary experts and scholars adopt the Delphi method to formulate the Chinese Expert Guidance on Overall Application of Lenvatinib in Hepatocellular Carcinoma after repeated discussions and revisions, in order to provide reference for reasonable and effective clinical application of lenvatinib for clinicians.
