The research progress of macrophage glycolysis in sepsis

VernacularTitle:巨噬细胞糖酵解在脓毒症中的研究进展
Author: Xing CAI ^{1
,

2} ; Xinglong MA ; Changjian ZHOU ; Peng XIE ; Songxuan SHEN ; Yanmei MIAO ; Jiamei SONG ; Leiyu XIE
Author Information

1. 遵义医科大学第三附属医院急诊科(贵州遵义 519100)
2. 遵义医科大学第三附属医院重症医学科(贵州遵义 519100)
Keywords: sepsis; macrophage; glycolysis
From: The Journal of Practical Medicine 2024;40(19):2783-2788
CountryChina
Language:Chinese
Abstract: Sepsis is a heterogeneous syndrome.It is caused by infections,attributing to immune dysfunction pathologically.The disease is characterized by macrophage-mediated inflammation and immune response throughout its development.During septic development,macrophages metabolize crucially with glycolysis remarkably enhanced.The glycolystic enhancement facilitates septic development by promoting the inflammatory response of macrophages and altering their phenotype.Therefore,direct or indirect inhibition of macrophagic glycolysis can alleviate sepsis and neutralize damages to organs functionally,promoting the polarization of anti-inflammatory phenotype.In this review,we aim to investigate the relationship between macrophagic glycolysis and sepsis,focusing on researching into relevant molecular mechanisms by which glycolysis is regulated for treating sepsis.It is concluded that interfer-ing with macrophagic glycolysis may serve as a novel therapeutic strategy for treating sepsis.