Effect of citicoline sodium combined with Eurekline on the expression of miR-17-5p and miR-29b in patients with ischemic stroke
10.3969/j.issn.1006-5725.2024.19.012
- VernacularTitle:胞磷胆碱钠联合尤瑞克林对缺血性脑卒中患者miR-17-5p、miR-29b表达的影响
- Author:
Baozhu ZHAO
1
;
Zhengming DU
;
Xiuxiu CHEN
Author Information
1. 海南医学院第一附属医院神经内科(海南海口 570102)
- Keywords:
citicoline sodium;
eurekline;
ischemic stroke;
miR-17-5p;
miR-29b
- From:
The Journal of Practical Medicine
2024;40(19):2733-2737
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of citicoline sodium and Ureicrin on the expression of miR-17-5p and miR-29b in patients with ischemic stroke.Methods A total of 100 patients with ischemic stroke treated in the hospital were divided into control group and combination group by random table method.From February 2023 to February 2024,they were respectively given Eurecrine monotherapy and citicoline sodium and eurecrine combination therapy.Cerebral blood perfusion indexes,inflammatory factors,oxidative stress,miR-17-5p,miR-29b levels and clinical efficacy were detected in the two groups,and adverse reactions were statistically recorded.Results There was no significant difference in CBF,CBV,hs-CRP,miR-29b,IL-6,TNF-α and miR-17-5p between the two groups before treatment(P>0.05).After treatment,the levels of CBF,CBV,miR-29b,SOD and GSH-Px increased,while the levels of hs-CRP,IL-6,TNF-α,miR-17-5p and MDA decreased,and the levels of CBF,CBV,miR-29b,SOD and GSH-Px in the combined group were higher than those in the control group.The levels of hs-CRP,TNF-α,IL-6,miR-17-5p and MDA were significantly different from those of the control group(P<0.05).The incidence of adverse reactions and the total effective rate of treatment in combination group were higher than those in control group(P<0.05),and the adverse reactions were mild and tolerable.Conclusion The combination of citicoline sodium and Ureicrin can improve the clinical efficacy and prognosis of patients.
