Association between miRNA-146a gene polymorphisms and ischemic post-stroke depression

VernacularTitle:miRNA-146a基因多态性与缺血性卒中后抑郁的相关性
Author: Jiawu FU ¹ ; Hao WU ; Zhimin LIAO ; Jing CHEN ; Junliang LI
Author Information

1. 广东医科大学附属医院神经内科(广东湛江 524000)
Keywords: miRNA-146a; ischemic post-stroke depression; gene polymorphisms; relative expression
From: The Journal of Practical Medicine 2024;40(19):2708-2712
CountryChina
Language:Chinese
Abstract: Objective To analyze the relationship of miRNA-146a gene polymorphisms and ischemic post-stroke depression(PSD).Methods The SNP rs2910164 in the miRNA-146a gene in 200 ischemic PSD patients(case group)and 200 ischemic non-PSD patients(control group)was analyzed using the SNaPshot technique.The relative expression levels of miRNA-146a in the peripheral blood of two groups were determined.Results The case group showed significantly different allele and genotype frequencies of the SNP rs2910164 as compared with the control group(G vs.C:P=0.003;GG+CG vs.CC:P=0.012).Meanwhile,the case group presented a significantly lower level of miRNA-146a relative expression(P<0.05).Within the control group,additionally,the subgroup of GG+CG genotypes demonstrated a significantly lower level of miRNA-146a relative expression compared with the subgroup of CC genotypes(P<0.05).Conclusion SNP rs2910164 in the miRNA-146a is associated with the susceptibility to ischemic PSD,and G allele may play a role in the ischemic PSD.