Research progress on the assembly and release mechanisms of coronaviruses
10.3969/j.issn.1006-5725.2024.18.025
- VernacularTitle:冠状病毒组装及释放机制的研究进展
- Author:
Kun YANG
1
,
2
;
Lan WANG
;
Zhihu ZHAO
;
Yan ZHANG
;
Guoying YU
Author Information
1. 河南师范大学生命科学学院(河南新乡 453007)
2. 河南省肺纤维化国际联合实验室(河南新乡 453007)
- Keywords:
coronavirus;
structural proteins;
packaging signal;
liquid-liquid phase separation;
re-lease;
targeted drug
- From:
The Journal of Practical Medicine
2024;40(18):2654-2659
- CountryChina
- Language:Chinese
-
Abstract:
In recent decades,the advent of coronaviruses has engendered multiple large-scale infectious outbreaks,leading to profound human casualties and posing a significant menace to global public health.At the crux of the coronavirus lifecycle,the assembly and release phases emerge as pivotal processes,necessitating meticulous investigation into the underlying mechanisms.This paper systematically expounds upon the intricate assembly and packaging mechanisms intrinsic to coronaviruses,scrutinizes the diverse release pathways employed by these viruses,and delves into the discourse surrounding targeted antiviral drugs.The comprehensive insights encapsulated in this exposition serve as valuable reference points for formulating effective strategies in the prevention and treatment of coronavirus infections.
