Advancements in CAR-T cell research for the treatment of colorectal cancer
10.3969/j.issn.1006-5725.2024.18.023
- VernacularTitle:CAR-T细胞在结直肠癌治疗方面的研究进展
- Author:
Zhaochen SUN
1
,
2
;
Jun-Yan JIANG
;
Yitian CHEN
Author Information
1. 南京大学医学院附属金陵医院肿瘤内科 (南京 210000)
2. 联勤保障部队第904医院血液肿瘤科 (江苏无锡 214000)
- Keywords:
CAR-T cells;
immunotherapy;
solid tumors
- From:
The Journal of Practical Medicine
2024;40(18):2640-2646
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor T-cell immunotherapy(CAR-T)represents a novel approach in cancer treatment that harnesses the anti-tumor immune response.In comparison to traditional immunotherapy,CAR-T exhibits enhanced tumor antigen specificity and cell cytotoxicity independent of major histocompatibility complex molecules.Recent advancements in CAR-T cell research have demonstrated remarkable clinical responses in patients with advanced leukemia and lymphoma by targeting CD19.Given the rising incidence of colorectal cancer,the success observed in hematological malignancies has prompted further investigation into the application of CAR-T therapy for solid tumors,including colorectal cancer.Regrettably,several clinical studies have failed to meet expectations.This article provides an overview of CAR-T cells'definition and structure,highlights existing challenges in solid tumor treatment,and specifically discusses the application and future prospects of CAR-T cell therapy for colorectal cancer.
