Research progress of mouse model of hepatitis B virus infection
10.3760/cma.j.cn501113-20210723-00353
- VernacularTitle:乙型肝炎病毒感染小鼠模型的研究进展
- Author:
Chao FAN
1
;
Chuantao YE
;
Ziyang GU
;
Xiaoyan WANG
;
Bibo KANG
;
Ying ZHANG
Author Information
1. 空军军医大学第二附属医院传染科，西安 710038
- Keywords:
Hepatitis B virus;
Viral infection;
Animal model;
Humanized mouse
- From:
Chinese Journal of Hepatology
2023;31(2):221-224
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection is a global health problem. Animal models are important for the study of the HBV infection mechanism. In the study related to the mouse model of HBV infection, the researchers have established a variety of mouse models, including transgenic, plasmid hydrodynamic injection, virus vector transfection, cccDNA cycle simulation, human and mouse liver chimerism, and liver/immune dual humanization, according to the characteristics of HBV infection. Herein, the research progress of these models is summarized. Notably, the application of these models can further clarify the mechanism of HBV infection under the conditions of a specific immune response in vivo and lay the foundation for the development of new antiviral drugs and immunotherapy for HBV infection.
