Effect of endoscopic tumor resection by submucosal tunnel on recurrence in patients with submucosal tumors around cardia
10.3969/j.issn.1006-5725.2024.18.008
- VernacularTitle:经黏膜下隧道内镜肿瘤切除术对贲门周围黏膜下肿瘤患者复发的影响
- Author:
Rui WANG
1
;
Duo LI
;
Zhao PENG
;
Lijun CUI
;
Xiang ZHANG
;
Kaili FAN
;
Wenyan WU
Author Information
1. 河北北方学院附属第一医院消化内科(河北张家口 050051)
- Keywords:
pericardial submucosal tumor;
submucous tunnel endoscopic tumor resection;
recur-rence;
quality of life;
indicators of inflammation;
immune index
- From:
The Journal of Practical Medicine
2024;40(18):2555-2560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of endoscopic tumor resection by submucosal tunnel(STER)on recurrence in patients with submucosal tumors(SMT)around cardia.Methods A total of 92 patients with SMT around cardia were selected and divided into the treatment group(n=46)and the control group(n=46)using random number table method.The treatment group and the control group were treated with STER and endoscopic submucosal dissection(ESD),respectively,and both groups were followed up for 12 months after surgery.Periop-erative indexes,therapeutic effects,quality of life,sleep,inflammatory indexes,immune indexes before and 1 week after surgery,complications 1 week after surgery,recurrence 12 months after surgery were compared between the two groups.Results Compared with the control group,the surgery time of the treatment group was longer,the hospital stay was shorter and treatment cost were lower,and the stripping speed was faster(P＜0.05).Compared with before surgery,scores of Pittsburgh sleep Quality index(PSQI),serum levels of interleukin-8(IL-8),inter-leukin-6(IL-6),high-sensitive C-reactive protein(hs-CRP)and whole blood levels of CD8+decreased in the two groups 1 week after surgery,and the levels were lower in the treatment group(P＜0.05).Compared with the preoperative results,the levels of whole blood CD4+and CD4+/CD8+,scores of Quality of Life Core 46 Questionnaire(QLQ-C46),Karnofsky Score(KPS)were higher in the two groups 1 week after surgery,those in the treatment group was higher(P＜0.05).1 week after surgery,the complication rate of the two groups was lower in the treat-ment group(P＜0.05),and 12 months after surgery,the recurrence rate of the two groups was not statistically significant(P＞0.05).Conclusion STER treatment for SMT around cardia was highly effective,resulting in superior perioperative outcomes,enhanced life and sleep quality,reduced systemic inflammation,and bolstered immune function.Moreover,it significantly lowered the risk of complications without raising the rates of recurrence.
