Advances in research on optimal dialysate bicarbonate concentration for maintenance hemodialysis patients

VernacularTitle:维持性血液透析患者最佳透析液碳酸氢盐浓度的研究进展
Author: Jingfang WAN ¹ ; Kehong CHEN
Author Information

1. 陆军军医大学大坪医院肾内科(重庆 400042)
Keywords: maintenance hemodialysis; dialysate bicarbonate; artificial intelligence; metabolic acido-sis; metabolic alkalosis
From: The Journal of Practical Medicine 2024;40(18):2520-2524
CountryChina
Language:Chinese
Abstract: Metabolic acidosis is a prevalent complication in patients undergoing maintenance hemodialysis(MHD).The maintenance of acid-base balance in MHD patients primarily relies on the total alkali supply in the dialysate.Achieving an optimal concentration of dialysate bicarbonate(DBIC)is crucial to prevent metabolic acidosis before subsequent hemodialysis sessions while avoiding metabolic alkalosis after the current session.Inad-equate correction or overcorrection of pre-dialysis metabolic acidosis has been associated with unfavorable patient outcomes;however,there is currently a lack of guidelines or expert consensus regarding DBIC concentration.This study addresses the epidemiology of metabolic acidosis in MHD patients,explores the relationship between DBIC concentration and acid-base disorders,and discusses recent advancements in determining the ideal DBIC concentration,providing valuable insights for formulating scientifically sound and personalized DBIC dialysis prescriptions.