Advances of TRIM superfamily proteins in chronic liver disease and hepatocellular carcinoma
10.3760/cma.j.cn501113-20220702-00363
- VernacularTitle:三结构域蛋白超家族在慢性肝病及肝癌中的研究进展
- Author:
Yu PENG
1
;
Hui QIAN
;
Xin ZHANG
;
Weifen XIE
Author Information
1. 海军军医大学附属长征医院消化内科，上海 200003
- Keywords:
TRIM protein;
Chronic liver disease;
Hepatocellular carcinoma
- From:
Chinese Journal of Hepatology
2022;30(12):1387-1391
- CountryChina
- Language:Chinese
-
Abstract:
The modification of proteins with ubiquitination is closely related to the occurrence and development of chronic liver disease and hepatocellular carcinoma. The tripartite motif (TRIM) family of proteins is one of the E3 ubiquitin ligase subfamily, which participates in various biological processes such as intracellular signal transduction, apoptosis, autophagy, and immunity by regulating the ubiquitination of target proteins. A growing body of research shows that the TRIM family of proteins plays an important role in chronic liver disease. This article systematically reviews the role and molecular mechanism of TRIM protein in the process of chronic liver disease, with the aim of exploring its potential application in the clinical diagnosis and treatment.
