Research progress on the correlation between oxidative stress and ferroptosis in diabetic impotence
10.3969/j.issn.1006-5725.2024.16.006
- VernacularTitle:氧化应激与铁死亡在糖尿病型阳痿中的相关性研究进展
- Author:
Ganggang LU
1
;
Shenglong LI
;
Yongqiang ZHAO
;
Yunpeng JIA
;
Yonglin LIANG
;
Yuanbo ZHAO
Author Information
1. 甘肃中医药大学中西医结合学院(兰州 730000)
- Keywords:
oxidative stress;
ferroptosis;
diabetic impotence;
mechanism of action;
research progress
- From:
The Journal of Practical Medicine
2024;40(16):2229-2235
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus erectile dysfunction(DMED)is a common diabetic-related vascular,endo-crine and neuropathy in clinical practice,and patients with DMED often present with symptoms such as difficulty in erection,prolonged erection time,poor hardness,and short sexual intercourse.The etiological mechanism is complex,and it is often closely related to many factors such as oxidative stress(OS),inflammatory response,and neurological and endocrine lesions,which often cross-react and promote the progression of DMED lesions.In recent years,relevant studies have shown that OS and ferroptosis play a key role in DMED:OS can cause neuro-logical and Abnormal endocrine function,decreased synthesis or bioavailability of penile vascular endothelium,spongy endothelial cell dysfunction and decreased smooth muscle diastolic function,resulting in penile erectile dysfunction,and ferroptosis has also been confirmed to be closely related to DMED,controlling OS and ferroptosis to improve erectile function in diabetic patients is a reasonable and effective treatment pathway,but the mechanism of action of ferroptosis leading to DMED needs to be further studied.Therefore,this article reviews the latest infor-mation on the correlation between OS and ferroptosis and DMED,aiming to provide a useful reference for exploring the mechanism of DMED,clinical prevention and treatment of DMED,and providing potential directions for future research in this field.
