Differentiation between hyperintense hepatocellular carcinoma and focal nodular hyperplasia in hepatobiliary phase with multimodal parameters of magnetic resonance imaging
10.3760/cma.j.cn501113-20200803-00432
- VernacularTitle:利用磁共振成像多模态参数鉴别肝胆期高信号的肝细胞癌与局灶性结节增生
- Author:
Ye LANG
1
;
Chunqiong MA
;
Liwei DENG
;
Jian WANG
;
Chen LIU
;
Shilei XIAO
;
Jiang DENG
;
Qian LI
;
Wenwen LIU
;
Desheng YANG
;
Xiaoming LI
Author Information
1. 陆军军医大学第一附属医院放射科，重庆 400038
- Keywords:
Magnetic resonance imaging;
Hepatocellular carcinoma;
Gd-EOB-DTPA;
Hyperintense in hepatobiliary phase;
Focal nodular hyperplasia
- From:
Chinese Journal of Hepatology
2022;30(10):1069-1073
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To differentiate hyperintense hepatocellular carcinoma (HCC) with focal nodular hyperplasia (FNH) in the hepatobiliary phase by MRI multimodal parameters.Methods:A retrospective cross-sectional study method was adopted. Clinical data on 15 cases with hyperintense HCC and 15 cases with FNH in the hepatobiliary phase admitted to the First Affiliated Hospital of the Army Medical University from January 2012 to December 2019 were collected. All patients with solitary lesions who underwent Gd-EOB-DTPA-enhanced MRI examinations were included. Surgically resected specimens were verified by pathological and immunohistochemical examination. HCC and FNH imaging features were analyzed by two radiologists.Results:(1) HCC and FNH apparent diffusion coefficient (ADC) values were 1 205.07±239.65×10 -3 mm 2/s and 1 434.73±217.6×10 -3 mm 2/s, respectively, and the SI ADC difference was statistically significant ( P<0.05) between the two groups. (2) In the dynamic contrast-enhanced MRI sequence, 15 cases of HCC were significantly enhanced in the arterial phase, of which 13 cases were characterized by continuous enhancement, and 2 cases were characterized by wash-in and wash-out enhancement. There was no statistically significant difference ( P>0.05) between the two groups. SI enhancement rate between HCC and FNH (1.39±0.60 vs. 1.33±0.50, P>0.05) had no significant difference. (3) HCC and FNH morphological features in the hepatobiliary phase included: annular hypointensity: HCC (8 cases) vs. FNH (0 cases); contrast filling defects: HCC (8 cases) vs. FNH (0 cases); linear hyposignal separation: HCC (10 cases) vs. FNH (0 cases); and stellate scars: HCC (0) vs. FNH (5 cases), and there were statistically significant differences ( P<0.05) between the two groups . Conclusion:Multimodal MRI have significant value for differentiating hyperintense HCC and FNH in the hepatobiliary phase.
