A new vision of diabetes classification:A shift from clinical manifestation to etiological molecular mecha-nism
10.3969/j.issn.1006-5725.2024.16.001
- VernacularTitle:糖尿病分型新视野——基于临床表现向基于病因分子机制转变
- Author:
Shuting YANG
1
;
Shuoming LUO
;
Zhiguang ZHOU
Author Information
1. 中南大学湘雅二医院代谢内分泌科,糖尿病免疫学教育部重点实验室,国家代谢性疾病临床医学研究中心(长沙 410011)
- Keywords:
diabetes classification;
etiological molecular mechanism;
early diagnosis;
precision medicine
- From:
The Journal of Practical Medicine
2024;40(16):2199-2205
- CountryChina
- Language:Chinese
-
Abstract:
The classification of diabetes is undergoing a significant transformation.As advancements in medical technology and a deeper understanding of its etiology,traditional classification methods based on clinical characteristics and insulin dependency are increasingly revealing their limitations.In recent years,the integration of genomic,epigenetic,and metabolomic technologies,combined with the application of big data analytics and machine learning in disease classification,has propelled diabetes classification towards enhanced precision and personalization.These cutting-edge technologies elucidate the intricate pathophysiological mechanisms and exten-sive heterogeneity inherent in diabetes,offering novel methodologies for early diagnosis,individualized treatment,and prognostic evaluation.This paradigm shift not only deepens the comprehension of diabetes complexity but also holds the potential to provide more precise and efficacious therapeutic interventions for patients.Consequently,this marks a historic transition from simplistic,clinically-based classification systems to sophisticated,molecular mechanism-based paradigms in diabetes classification.
