Research progress on the intervention of traditional Chinese medicine in IBS-D based on the"SCFAs-intes-tinal barrier"pathway
10.3969/j.issn.1006-5725.2024.15.023
- VernacularTitle:基于"短链脂肪酸-肠屏障"途径探讨中药在腹泻型肠易激综合征中的干预研究进展
- Author:
Xin DOU
1
;
Changhui HE
;
Xiao MEI
;
Haidi PAN
;
Yuanxin MA
;
Wei WANG
Author Information
1. 山东中医药大学 第一临床医学院(济南 250355)
- Keywords:
SCFAs-intestinal barrier;
diarrhea-predominant irritable bowel syndrome;
large intestine dominating fluid;
traditional Chinese medicine monomers/compounds;
Chinese medicine compound;
research progress
- From:
The Journal of Practical Medicine
2024;40(15):2177-2182
- CountryChina
- Language:Chinese
-
Abstract:
Diarrhea-predominant irritable bowel syndrome(IBS-D)is a clinically common functional gastrointestinal disease,the"SCFAs-intestinal barrier"pathway plays an important role in the pathogenesis of IBS-D.Traditional Chinese medicine monomers/compounds or Chinese medicine compound can treat IBS-D by regulating the"SCFAs-intestinal barrier"through multiple pathways and multiple targets.This article takes the relationship between SCFAs and the four major intestinal barriers,as well as the mediating effect of IBS-D,as the starting point to systematically review and sort out the relevant literature on the targeted regulation of"SCFAs-intestinal barrier"in the treatment of IBS-D by Traditional Chinese medicine monomers/compounds and Chinese medicine compound;explores the theoretical basis of IBS-D caused by"SCFAs-intestinal barrier"from the perspective of"Large intes-tine dominating fluid",in order to provid ideas for Traditional Chinese medicine to establish a precision treatment system with Chinese medicine characteristics.
