Analysis and significance of HBV DNA below the lower detection limit of HBV RNA levels after long-term NAs antiviral therapy in patients with hepatitis B virus cirrhosis
10.3760/cma.j.cn501113-20201126-00629
- VernacularTitle:经NAs长期治疗后HBV DNA低于检测下限乙型肝炎肝硬化患者的HBV RNA水平分析及其意义
- Author:
Chunyan WANG
1
;
Yu CAO
;
Yongmei FENG
;
Jing LI
;
Bei JIANG
;
Yan ZHANG
;
Jun WEN
;
Yujin ZHU
;
Jia LI
Author Information
1. 天津市第二人民医院肝病科，天津 300192
- Keywords:
Liver cirrhosis;
Hepatitis B virus;
Nucleotide analogue;
DNA;
RNA
- From:
Chinese Journal of Hepatology
2022;30(7):758-762
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the significance of HBV DNA below the lower detection limit of HBV RNA levels after long-term nucleos(t)ide analogues (NAs) antiviral therapy in patients with hepatitis B virus cirrhosis.Methods:97 cases with hepatitis B virus cirrhosis treated with NAs antiviral therapy for at least 3 years between May 2018 to July 2019 were selected. High-sensitivity HBV DNA (<20 IU/ml), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), HBsAg, HBeAg and HBV RNA at least twice every 6 months were detected. According to Child-Pugh classification, HBeAg, HBsAg level, and HBV RNA level intergroup comparison was performed. Rank sum test, χ2 test and linear regression analysis were performed on the data. Results:Compared with the HBV RNA level of child-Pugh class A patients, the HBV RNA level of Child-Pugh class B+C patients were significantly higher [4.1 (0,4.9) log 10 copies/ml and 2.0 (0,3.5) log 10 copies/ml], and the difference was statistically significant ( Z=2.370, P<0.05). According to different HBeAg levels, they were divided into HBeAg positive and negative group, and the quantitative comparison of HBV RNA levels between the two groups were 2.0 (0, 4.5) log 10 copies/ml and 1.0 (1.0, 2.0) log 10 copies/ml, respectively, and the difference was statistically significant ( Z=3.233, P<0.05). According to different HBsAg levels, they were divided into three groups: HBsAg≤100 IU/ml, 100
