Research progress of statins in the prevention and treatment of colorectal cancer
10.3969/j.issn.1006-5725.2024.14.024
- VernacularTitle:他汀类药物在结直肠癌防治中的研究进展
- Author:
Mingxin TANG
1
;
Xiaolin WANG
;
Xuanfei LI
Author Information
1. 华中科技大学同济医学院附属梨园医院消化内科(武汉 430077)
- Keywords:
statins;
colorectal cancer;
prevention and treatment
- From:
The Journal of Practical Medicine
2024;40(14):2041-2046
- CountryChina
- Language:Chinese
-
Abstract:
Statins,known as hydroxymethylglutaryl coenzyme A reductase(HMG-CoA)inhibitors,are primarily used to lower blood lipids,preventing and treating cardiovascular diseases.Research indicates that statins exhibit multiple effects in the prevention and treatment of colorectal cancer.They function by inhibiting the MVA pathway,suppressing inflammation,enhancing cellular immunity,and influencing the gut microbiota,positively impacting the onset and progression of colorectal cancer.Clinical studies have additionally uncovered that statin drugs can augment the effectiveness of chemotherapy,immunotherapy,and adjuvant therapies,acting as both pre-ventive and adjunctive measures for colorectal cancer.This article critically reviews the research progress on statins in colorectal cancer,aiming to establish a theoretical foundation for exploring innovative treatment options.
