Research progress on the regulation of intestinal flora on glioma

VernacularTitle:肠道菌群对胶质瘤的调控作用研究进展
Author: Kexin XI ¹ ; Yuqi ZHAO ; Xiaoting XIE ; Yuntao LU ; Hongying FAN ; Xiaoyan HE
Author Information

1. 南方医科大学广东省热带病研究重点实验室BSL-3实验室(广州 510515)
Keywords: intestinal flora; glioma; brain-gut axis
From: The Journal of Practical Medicine 2024;40(14):2027-2030
CountryChina
Language:Chinese
Abstract: Glioma is the most common primary tumor of the brain,accounting for 81%of central nervous system(CNS)malignant tumors.The degree of malignancy is high,and the current treatment methods are limited.In recent years,with the in-depth study of intestinal flora and brain-gut axis,it has been found that the diversity of gut microbiota plays an important role in the regulation of glioma.The mechanism is that the intestinal flora affects the development of glioma through the role of immune regulation and metabolites.In addition,it has been con-firmed that there is a certain correlation between some probiotics and glioma,which provides a new application prospect for the treatment of glioma.This paper discusses the main intestinal bacteria that regulate gliomas as well as the role and regulatory mechanisms of intestinal flora in the development of gliomas,and provides ideas for the discovery of new targets for glioma treatment and further improvement of treatment options.