Reversal mechanism of hepatic fibrosis
10.3760/cma.j.cn501113-20220504-00239
- VernacularTitle:肝纤维化的逆转机制
- Author:
Jingshu QI
1
;
Xudong HU
;
Chenghai LIU
Author Information
1. 上海中医药大学附属曙光医院肝病研究所，上海 201203
- Keywords:
Liver fibrosis;
Regression;
Mechanism;
Hepatocyte;
Hepatic stellate cell;
Liver sinusoidal endothelial cells;
Hepatic macrophage;
Matrix metalloproteinases
- From:
Chinese Journal of Hepatology
2022;30(6):577-582
- CountryChina
- Language:Chinese
-
Abstract:
There is an increasing histological clinical evidence that both hepatic fibrosis and some degree of cirrhosis reversal can improve prognosis. Hepatic fibrosis involves a variety of cells and steps, and its reversal mechanism is also very complex, mainly including the reduction of hepatocyte necrosis and regeneration, the apoptosis and inactivation of activated hepatic stellate cells, and the reversal of hepatic sinusoidal endothelial cells and microvessels, restorative hepatic macrophages polarization and cell-to-cell interactions. Furthermore, the biochemical basis for reversal of hepatic fibrosis is decreased expression of matrix metalloproteinase inhibitors, up-regulation of matrix metalloproteinase activity, and increased degradation of extracellular matrix. However, at present, there are few studies on the clinicopathological mechanism of liver fibrosis reversal, and the key target groups of different etiologies with different degrees are still unclear, and the corresponding translational application research is lacking. Therefore, an in-depth and systematic understanding of the characteristics and mechanisms of hepatic fibrosis reversal can not only enrich the understanding of the natural history of hepatic fibrosis and cirrhosis, but also provide reference for the development and clinical application of anti-hepatic fibrotic drugs.
