Activation of cGAS/STING signaling pathway and its immunological role in the progression of nonalcoholic fatty liver disease
10.3760/cma.j.cn501113-20211011-00503
- VernacularTitle:非酒精性脂肪性肝病进展中cGAS/STING信号通路激活及其免疫学作用
- Author:
Chunxiu SHA
1
;
Linling JU
;
Ping ZHOU
;
Dengfu YAO
;
Min YAO
Author Information
1. 南通大学医学免疫学系，南通 226001
- Keywords:
Non-alcoholic fatty liver disease;
cGAS/STING signaling pathway;
Abnormal lipid metabolism;
Chronic liver disease
- From:
Chinese Journal of Hepatology
2022;30(5):564-568
- CountryChina
- Language:Chinese
-
Abstract:
Today, nonalcoholic fatty liver disease remains the most dominant chronic liver disease. Cyclic guanosine monophosphate-adenosine monosphosphate synthase (cGAS) is a cytosolic DNA sensor that catalyzes the synthesis of cyclic guanosine monophosphate, activates stimulator of interferon genes (STING), and releases type-I interferon cytokines to trigger immune responses. Exogenous or endogenous DNA acts as a cGAS ligand to activate the cGAS-STING signaling pathway, which plays a role in hepatitis, nonalcoholic fatty liver disease, liver cancer and other diseases, and affects liver disease progression and metabolism through mechanisms such as autophagy. This article reviews the activation of cGAS-STING pathway and its molecular immunological role in nonalcoholic fatty liver disease progression.
