Research progress in biological role of TIGIT and its application in bladder cancer
10.3969/j.issn.1006-5725.2024.12.025
- VernacularTitle:TIGIT的生物学作用及其在膀胱癌中应用的研究进展
- Author:
Yawei ZHANG
1
;
Hon-Gjin SHI
;
Shi FU
;
Jiansong WANG
;
Haifeng WANG
Author Information
1. 昆明医科大学第二附属医院泌尿外科/云南省泌尿外科研究所(昆明 650101)
- Keywords:
TIGIT;
bladder cancer;
CD155;
immuno-inhibitory receptor;
immunotherapy
- From:
The Journal of Practical Medicine
2024;40(12):1762-1766
- CountryChina
- Language:Chinese
-
Abstract:
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain(TIGIT)is a transmembrane glycoprotein expressed on the surface of immune cells.TIGIT expression is up-regulated in blad-der cancer and will have an important impact on bladder cancer development and poor prognosis.Immunotherapy that blocks TIGIT signaling is expected to improve the prognosis of bladder cancer.With further research,TIGIT is likely to become a target for bladder cancer diagnosis and treatment.This article reviews the structure,immuno-modulatory effect and the research progress of TIGIT in bladder cancer.
