Advances in the role of extracellular histones in the inflammatory process of liver injury
10.3760/cma.j.cn501113-20200403-00159
- VernacularTitle:细胞外组蛋白在肝损伤炎症过程中的作用进展
- Author:
Chunxia SHI
1
;
Yao WANG
;
Qian CHEN
;
Fangzhou JIAO
;
Maohua PEI
;
Zuojiong GONG
Author Information
1. 武汉大学人民医院感染科 430060
- Keywords:
Extracellular histones;
Liver injury;
Inflammation
- From:
Chinese Journal of Hepatology
2021;29(11):1124-1127
- CountryChina
- Language:Chinese
-
Abstract:
Histones are important structural proteins of chromatin in the nucleus, which can regulate gene transcription, and can be released from the nucleus to the outside of the cell under injury and inflammatory stimulations, thereby causing cytotoxicity and immune stimulation, and aggravating tissue damage. Extracellular histones are involved in the occurrence and development of many diseases, including sepsis, autoimmune diseases, liver injury, and acute lung injury. Therefore, its application not only can be used as a body’s biomarker of inflammation, but also it is expected to become a molecular target for the treatment of diseases. This article reviews the role of extracellular histones in the inflammatory process of liver injury.
