Correlational verification of drug-induced liver injury with HLA-B*35:01 allele due to Polygonum multiflorum
10.3760/cma.j.cn501113-20210702-00312
- VernacularTitle:何首乌导致药物性肝损伤与HLA-B*35∶01等位基因的相关性验证
- Author:
Deliang HUANG
1
;
Chaopeng LI
;
Jiabo WANG
;
Fang LUO
;
Zhijie CHEN
;
Zhibin ZHU
;
Huiyi LAI
;
Qingxian CAI
;
Jun CHEN
Author Information
1. 深圳市第三人民医院/南方科技大学第二附属医院 肝病医学中心，深圳 518100
- Keywords:
Fleeceflower root (He-shou-wu);
Drug-induced liver injury;
Susceptible population;
HLA-B*35:01;
Verification;
Prediction
- From:
Chinese Journal of Hepatology
2021;29(11):1106-1108
- CountryChina
- Language:Chinese
-
Abstract:
In order to verify the correlation between Polygonum multiflorum-induced liver injury and HLA-B*35 : 01 alleles, six hospitalized patients diagnosed with Polygonum multiflorum-induced liver injury (PM-DILI) were selected, and their clinicopathological data were collected. Simultaneously, blood HLA-B* 35 : 01 allele detection was performed. Among the six PM-DILI cases, 4 were male, aged 38.83 ± 10.13 years old. The types of liver injury were hepatocellular injury types in all, and the severity of liver injury in five cases was grade 3. The histological presentations were acute hepatitis and acute cholestatic hepatitis. PM-DILI cases were all HLA-B*35:01 carriers, with a carrier rate of 100%. This finding indicates that PM-DILI is significantly correlated with HLA-B*35:01 alleles. Therefore, HLA-B*35 : 01 alleles can be used as an important predictive indicator for PM-DILI.
