AGT rs5051 gene polymorphism increases the risk of coronary heart disease in patients with non-alcoholic fatty liver disease in the Han Chinese population
10.3760/cma.j.cn501113-20210106-00008
- VernacularTitle:AGT rs5051基因多态性增加中国汉族人群非酒精性脂肪性肝病患者发生冠心病的风险
- Author:
Mengzhen DONG
1
;
Zhonghua LIN
;
Shousheng LIU
;
Yongning XIN
;
Shiying XUAN
Author Information
1. 青岛大学附属青岛市市立医院感染性疾病科，青岛 266011
- Keywords:
Gene polymorphism;
Nonalcoholic fatty liver disease;
Coronary heart disease;
AGT rs5051
- From:
Chinese Journal of Hepatology
2021;29(11):1095-1100
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the angiotensinogen (AGT) rs5051 single nucleotide polymorphism (SNP) and the onset risk of coronary heart disease (CHD) in patients with non-alcoholic fatty liver disease (NAFLD) in the Han Chinese population.Methods:A total of 454 subjects were enrolled in this study. Among them, 140 cases were with NAFLD, 112 cases with NAFLD combined with CHD, and 202 healthy controls. Blood samples of all subjects were examined for biochemical indexes. Genotype at AGT rs5051 locus was detected by polymerase chain reaction. SPSS 21.0 statistical software was used for data statistical analysis.Results:The differences in distribution of AGT rs5051 genotypes and alleles between the NAFLD and the control group were not statistically significant ( P > 0.05). The differences in the distribution of AGT rs5051 genotypes and alleles between the NAFLD combined with CHD and the NAFLD group were statistically significant ( χ2 = 10.32, P = 0.001; χ2 = 11.72, P < 0.001). Binary logistic regression analysis results showed that TC + CC genotype had increased the occurrence risk of CHD in NAFLD patients ( OR = 2.203, 95% CI: 1.322 ~ 3.670, P = 0.02) than AGT rs5051 TT genotype carriers. After adjusting for gender, age, and body mass index, the TC + CC genotype still significantly increased the occurrence risk of CHD in NAFLD patients ( OR = 2.378, 95% CI: 1.384 ~ 4.087, P = 0.02). In addition, AGT rs5051 C allele mutations had significantly increased the occurrence risk of CHD in patients with NAFLD ( OR = 2.018 before adjustment, 95% CI: 1.345 ~ 3.027, P = 0.001; OR = 2.161, 95% CI: 1.406 ~ 3.322 after adjustment. P < 0.001). Conclusion:This study is the first to report the correlation between AGT rs5051 polymorphism and the occurrence risk of CHD in patients with NAFLD in Han Chinese population. AGT rs5051 polymorphism can significantly increase the risk of CHD in patients with NAFLD.
