Effects of indobuprofen combined with nicodil on inflammatory factors,myocardial injury markers and platelet function in patients with ACS after PCI
10.3969/j.issn.1006-5725.2024.12.016
- VernacularTitle:吲哚布芬联合尼可地尔对ACS患者PCI术后炎症因子、心肌损伤标志物和血小板功能的影响
- Author:
Shuhong RUI
1
;
Chenfang WANG
;
Yunhe LI
;
Junlan PAN
;
Jianlou WANG
Author Information
1. 河北中医药大学第二附属医院重症医学科(河北定州 073000)
- Keywords:
indobuprofen;
nicordil;
acute coronary syndrome;
markers of myocardial injury;
platelet function;
inflammatory factor
- From:
The Journal of Practical Medicine
2024;40(12):1706-1711
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of indobuprofen combined with nicodil for the treatment of acute coronary syndromes(ACS)and the effects of percutaneous coronary intervention on patients Effects of myocardial injury markers,platelet function and inflammatory factors after intervention(PCI).Method A total of 150 patients with ACS admitted to the hospital from January 2021 to December 2022 were divided into groups according to different treatment methods.The control group(n=75)was given nicodil combined with antiplatelet therapy,and the study group(n=75)was given indobufen combined with nicodil combined with antiplatelet therapy.Both groups were treated for 2 weeks.The clinical efficacy of the two groups was compared,the changes of myocardial injury markers,platelet function and inflammatory factors before and after treatment were monitored,and the total incidence of adverse reactions was recorded.Results The total effective rate of the group treated with nicodil combined with indobufen was 98.67%higher than that of the control group treated with nicodil alone,90.67%(χ2=4.754,P<0.05).The levels of myocardial injury markers such as cTnI and CK-MB in the study group after treatment were lower than those in the control group(t=15.492,3.250,P<0.05).The levels of platelet function indexes such as CD62p,CD63,GPⅡb/Ⅲa in the study group after treatment were lower than those in the control group(t=2.034,3.257,2.221,P<0.05).The levels of CRP,TNF-α,IL-6 and other inflammatory factors in the study group were lower than those in the control group after treatment(t=21.862,3.378,2.131,P<0.05).The total incidence of adverse reactions after treatment was 4.00%in the study group and 2.67%in the control group(P>0.05).Conclusion The efficacy of indobufien combined with nicodil in the treatment of ACS is better than that of nicodil alone,and it can improve myocardial injury and platelet function after PCI,inhibit the release of inflammatory factors,and the incidence of adverse reactions is lower.
