The mechanisms of the translation of polymerase from HBV pregenomic RNA
10.3760/cma.j.cn501113-20210808-00384
- VernacularTitle:乙型肝炎病毒前基因组RNA选择性翻译聚合酶蛋白的机制
- Author:
Danjuan LU
1
;
Huiling ZHENG
;
Jingyuan XI
;
Ting ZHANG
;
Xiangmei CHEN
;
Fengmin LU
Author Information
1. 北京大学医学部基础医学院 病原生物学系暨感染病中心，北京 100191
- Keywords:
Hepatitis B virus;
Pregenomic RNA;
Polymerase;
Selective translation
- From:
Chinese Journal of Hepatology
2021;29(10):1035-1040
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) is an important pathogen that causes different liver diseases such as viral hepatitis and liver cirrhosis. HBV pregenomic RNA (pgRNA) plays a crucial role in HBV life cycle, which is not only the translation template of core (C) and polymerase (P), but also the template of reverse transcription. The ratio of P protein to core protein is tightly regulated. Since P and core are both translated by pgRNA and the open reading frame (ORF) of P is located downstream of the ORF of core, how to initiate P protein translation is a key scientific question. Previous studies suggest that P can be translated through different mechanisms, such as leaky scanning and reinitiation. In this review, we summarized the proposed mechanisms relevant to the translation of polymerase from HBV pgRNA through literature review and derivation.
