Regulatory effect of molecular targeted drugs on the immune system for liver cancer
10.3760/cma.j.cn501113-20191006-00363
- VernacularTitle:肝癌分子靶向药对免疫系统的调节作用
- Author:
Xiao CHENG
1
;
Jinzhang CHEN
;
Yabing GUO
Author Information
1. 广州南方医科大学南方医院感染内科 510515
- Keywords:
Liver cancer;
Targeted therapy;
Immunotherapy;
Immunoloregulation
- From:
Chinese Journal of Hepatology
2021;29(10):1031-1034
- CountryChina
- Language:Chinese
-
Abstract:
Molecular targeted drugs are the first choice for systemic treatment of liver cancer. In the past decade, several anti-liver cancer targeted drugs have been launched. More recently, immunotherapy has become a dazzling nova in the field of systemic treatment of liver cancer. Nivolumab and pembrolizumab have been approved as second-line treatments for patients with advanced hepatocellular carcinoma treated with sorafenib. However, the effect of single-agent treatment is always unsatisfactory in advanced liver cancer. An increasing number of evidences suggests that molecular targeted drugs have important immunomodulatory effects for liver cancer, and several targeted combined immunotherapies have also shown promising clinical effectiveness. This paper reviews the immunomodulatory effects of several molecular targeted drugs in the field of liver cancer.
