Analysis of clinical characteristics of patients with hyperthyroidism combined with liver injury
10.3760/cma.j.cn501113-20210906-00451
- VernacularTitle:甲状腺功能亢进症合并肝损伤患者的临床特点分析
- Author:
Qiuju SHENG
1
;
Yang DING
;
Chong ZHANG
;
Chao HAN
;
Yanwei LI
;
Yaoxin FAN
;
Xiaoguang DOU
Author Information
1. 中国医科大学附属盛京医院感染科，沈阳 110022
- Keywords:
Hyperthyroidism;
Antithyroid drugs;
Liver injury;
Treatment
- From:
Chinese Journal of Hepatology
2021;29(10):967-971
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze, explore and evaluate the clinical characteristics, abnormal thyroid function and follow-up of anti-hyperthyroidism treatment mode in patients with hyperthyroidism (commonly abbreviated as HT) combined with liver injury.Methods:The clinical data of patients with hyperthyroidism combined with liver injury were retrospectively analyzed, and then patients were divided into treated and untreated group according to whether they received anti-hyperthyroidism treatment before the consultation. Patients’ thyroid and liver function test indicators at the time of treatment were analyzed to determine the main cause of liver injury. The characteristics of liver injury were analyzed in the treatment group. Patients with severe thyroid toxicity and hyperthyroidism combined with liver injury were followed-up with anti-hyperthyroid therapy, mainly low-dose methimazole (MMI) and radioactive iodine therapy to evaluate its efficacy and safety. The comparison between data groups was performed by t-test, rank sum test and χ2 test. Results:Among the 43 cases with hyperthyroidism combined with liver injury, 19 were males and 24 were females, aged 49.0 ± 14.6 years-old; 16 cases (16/43, 37.21%) aged 40 to≤60 years- old, and 15 cases (15/43, 34.88%) aged > 60 years-old. There were 22 untreated cases (untreated group, accounting for 51.16%), and 21 treated cases with anti-hyperthyroidism (treatment group, accounting for 48.84%) at the time of consultation. Thyroid function indicators (FT3, FT4, TSH) and liver function indicators (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, γ-glutamyltransferase, total bilirubin) of the two groups were compared, and the difference was not statistically significant ( P > 0.05). The order of liver injury from mild to severe in patients with different treatment options were: methimazole (MMI) < propylthiouracil < radioactive iodine
