Clinical features of Epstein-Barr virus infection associated to liver injury in adolescents and adults
10.3760/cma.j.cn501113-20210902-00445
- VernacularTitle:青少年和成人EB病毒感染相关肝损伤的临床特征
- Author:
Jinghang XU
1
;
Yanyan YU
;
Xiaoyuan XU
Author Information
1. 北京大学第一医院感染疾病科 100034
- Keywords:
Hepatitis;
Liver injury;
Cholestasis;
Liver failure;
Epstein-Barr virus;
Infectious mononucleosis
- From:
Chinese Journal of Hepatology
2021;29(10):915-918
- CountryChina
- Language:Chinese
-
Abstract:
Epstein-Barr virus (EBV) infection is closely associated to liver injury with diverse clinical features in adolescents and adults. It is often manifested as infectious mononucleosis syndrome, sometimes causing self-limited acute hepatitis, with mild to moderate elevation of liver transaminases, and relative increase in age-related conditions. EBV infection can also cause cholestatic hepatitis, with elevated alkaline phosphatase and γ-glutamyltransferase as the main manifestations, accompanied by varying degrees of jaundice. A small number of patients with severe EBV infection may experience liver failure, and if left untreated in time, it may lead to high mortality. In addition, EBV infection is also associated with chronic hepatitis, liver cirrhosis, autoimmune liver disease, etc.
