Research progress on the relationship between Wnt signaling pathway and neural tube defects
10.3969/j.issn.1006-5725.2024.11.022
- VernacularTitle:Wnt信号通路与神经管畸形关联性研究进展
- Author:
Min HU
1
;
Yi RU
;
Liangqi XIE
;
Zhi CHAI
;
Huijie FAN
Author Information
1. 山西中医药大学神经生物学研究中心,国家中医药管理局多发性硬化益气活血重点研究室(山西晋中 030619)
- Keywords:
neural tube defects;
Wnt/β-catenin pathway;
planar cell polarity pathway;
Wnt/Ca2+pathway
- From:
The Journal of Practical Medicine
2024;40(11):1597-1601
- CountryChina
- Language:Chinese
-
Abstract:
Neural tube defects are a common neurodevelopmental disease,which can be divided into open and closed types.The main symptoms are anencephaly,encephalocele and cranial spina bifida.The relationship between Wnt signaling and neurogenesis has been a popular area in recent years.The Wnt signaling pathway includes Wnt/β-catenin,planar polar cell pathway and Wnt/Ca2+pathway,which plays an important role in neural tube development.This article reviews the current state of research on the Wnt signaling pathway and elucidates the role it plays in the process of neural tube closure,providing insights for the development of drugs related to the prevention and treatment of neural tube defects.
