Role of exosomal miRNA in tumor progression and its possible mechanism

VernacularTitle:外泌体miRNA在肿瘤进展中的作用及其可能机制
Author: Lun WU ¹ ; Zhigang TANG ; Shengwei LI ; Wei WANG ; Lin YE ; Lichao YAO
Author Information

1. 湖北医药学院附属国药东风总医院　442008
Keywords: Exosome; microRNA (miRNA); Tumor
From: Chinese Journal of Hepatology 2021;29(9):908-912
CountryChina
Language:Chinese
Abstract: Exosome is a kind of biological nano-vesicle with a diameter of about 30-100 nm and is synthesized, secreted, and released in almost all types of body cells. Recent studies have found that exosomes contain a variety of functional proteins, including mRNA and microRNAs (miRNAs) and so on, which play an important role in the process of material transfer and information exchange in cells. In addition, the related-exosomal microRNAs secreted by tumor cells play an important role in regulating theoccurrence, development, invasion and metastasis of tumors and other biological processes.. Therefore, the study of tumor-related exosomal microRNAs will help us to explore the mechanism of tumor progression from the perspective of tumor gene regulation and new tumor markers, which will contribute to the early diagnosis, treatment, disease monitoring and prognosis evaluation.