Expression of Intercellular Adhesion Molecule-1 and E-Selectin in Gastric Cancer and Their Clinical Significance.
10.5230/jgc.2012.12.3.140
- Author:
Woo Chul JUNG
1
;
You Jin JANG
;
Jong Han KIM
;
Sung Soo PARK
;
Seong Heum PARK
;
Seung Joo KIM
;
Young Jae MOK
;
Chong Suk KIM
Author Information
1. Department of Surgery, Korea University College of Medicine, Seoul, Korea. ppongttai@gmail.com
- Publication Type:Original Article
- Keywords:
Stomach neoplasms;
Intercellular adhesion molecule-1;
E-selectin
- MeSH:
Blotting, Western;
Cell Adhesion Molecules;
E-Selectin;
Humans;
Incidence;
Intercellular Adhesion Molecule-1;
Lymph Nodes;
Neoplasm Metastasis;
Recurrence;
Stomach Neoplasms
- From:Journal of Gastric Cancer
2012;12(3):140-148
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer. MATERIALS AND METHODS: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients. RESULTS: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively). CONCLUSIONS: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.
