The correlations of serum Aβ1-42,P-Tau181,and Hcy levels with sleep disorders in Parkinson's disease patients
10.3969/j.issn.1006-5725.2024.11.003
- VernacularTitle:血清Aβ1-42、P-Tau181和Hcy与帕金森病患者睡眠障碍的相关性
- Author:
Yanyun LI
1
;
Xueping CHEN
;
Peipei TIAN
;
Ting BAI
;
Qin GUO
;
Miao GUO
Author Information
1. 新疆生产建设兵团医院(石河子大学医学院第二附属医院)康复科(乌鲁木齐 830002)
- Keywords:
Parkinson's disease;
sleep disorder;
Aβ1-42;
P-Tau181;
Hcy;
correlation
- From:
The Journal of Practical Medicine
2024;40(11):1483-1487
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of serum Aβ1-42,P-Tau181,and Hcy levels with sleep disorders in patients with Parkinson's disease(PD).Methods A total of 80 PD patients were divided into a normal sleep group(＜7 points)and a sleep disorder group(≥7 points)based on the evaluations with Pittsburgh Sleep Quality Index(PSQI).Univariate and multivariate logistic regression analyses were performed to investigate the correlations between the levels of serum A β1-42,P-Tau181,and Hcy levels and sleep disorders.Receiver operating characteristic(ROC)curves were used to analyze the efficacy parameters of different indicators in pre-dicting sleep disorders in those patients.Results Univariate and multivariate logistic regression analyses showed that serum Aβ1-42 and Hcy were protective and independent risk factors for sleep disorders in the PD patients,respectively(P＜0.05).The predictive AUCs of serum Aβ1-42 and Hcy levels for sleep disorders in the PD patients were 0.757(95%CI:0.652～0.861)and 0.796(95%CI:0.688～0.905),respectively.Conclusion The levels of serum Aβ1-42 and Hcy in PD patients are closely related to sleep disorders.Therefore,they can be used as predic-tive factors for clinical diagnosis of PD with sleep disorders.
