Mechanism of action of dysregulated mitochondrial quality control system mediating Parkinson's disease
10.3969/j.issn.1006-5725.2024.11.002
- VernacularTitle:线粒体质量控制系统失调介导帕金森病的作用机制
- Author:
Juan LIU
1
;
Yanjie LI
;
Hewei QIN
;
Luyao MA
;
Nannan ZHAO
;
Huimin DING
Author Information
1. 河南中医药大学康复医学院(郑州 450046)
- Keywords:
Parkinson's disease;
mitochondrial quality control;
mitochondrial biogenesis;
mito-chondrial dynamics;
mitochondrial autophagy
- From:
The Journal of Practical Medicine
2024;40(11):1479-1482
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)is a common neurodegenerative disease with a complex pathogenesis,and a large number of studies have shown that mitochondrial dysfunction is an important causative factor for PD,whereas dysregulation of mitochondrial quality control is a key factor leading to mitochondrial dysfunction,and that aberrant mitochondrial biogenesis,fusion/fission imbalance,and mitochondrial hyperautophagy are closely associated with the onset of PD,but the role of the mitochondrial quality control system in the progression of PD is unclear.Therefore,this paper reviews the mechanism of mitochondrial quality control system in PD,with the aim of providing new ideas and theoretical basis for the clinical prevention and treatment of PD.
