Markers of gut flora in Parkinson's disease:A literature review

VernacularTitle:帕金森病的肠道菌群标志物研究进展
Author: Yanwei HUANG ¹ ; Kaitai ZENG ; Ziqi WEN ; Yan LI ; Rongping CHEN
Author Information

1. 南方医科大学(广州 510515)
Keywords: Parkinson's disease; intestinal flora; markers
From: The Journal of Practical Medicine 2024;40(11):1473-1478
CountryChina
Language:Chinese
Abstract: Parkinson's disease(PD)challenges us to assess the disease due to the lack of definitive biomarkers.Currently,PD patients have been found to contract several gastrointestinal comorbidities such as con-stipation and intestinal inflammation that precede its symptomatic manifestations.These conditions are intricately linked to proliferative metabolisms of the gut microbiota,which are manifested to be some primary changes in the gut microbiota or other changes involved in medication during treatment.In this paper we review the recent research on gut microbiota biomarkers in PD,arguing for the clinical relevance of gut microbiota as a marker in the progression of PD and prospecting the potential efficacy of fecal microbiota transplantation as an intervention in managing PD.